Using lauric acid and dodecylamine as template, Ti(SO4)2 and NH4VO3 as metal source, a kind of vanadium-titanium mixed oxides mesoporous material with various V/Ti molar ratios was first synthesized in sol-gel method. And then the final product was obtained, after being calcinated, and characterized by XRD and BET. The results indicated that the material is of mesoporous structure. Part of the vanadium incorporated into the material structure, while the rest might remain at the surface of mesoporous pores in the form of V2O5, n(V)/n(Ti) reaching 0.43. Then with the increase of n(V)/n(Ti) the pore diameter increase while the uniformity of the structure decreased. The material exhibited a good catalytic activity in the reaction of benzene hydroxylation.